Curriculum vitae

Drosophila melanogaster expresses 40 and 50 types of Olfactory receptor Neurons (ORNs) on its antennae and maxillary palps. Each of these neurons carries one specific type of odorant receptor (OR). ORs are differently tuned to odor molecules and thus may be characterized by their individual molecular receptive range (MRR) and its width (specific vs. broadly tuned). Since different ORs may be activated by single odorants in different manner, OR response profiles are largely overlapping and shape the global response profile.

In order to better understand the constraints underlying global odor response profiles, we need to characterize the function of the entire set of ORs, embedded in their original system. Making use of the ability to genetically modify Drosophila melanogaster, I follow an in-vivo approach combining calcium imaging and high throughput robotic techniques to automatically apply a large number of single odorants and mixtures.

Strauch M, Lüdke A, Münch D, Laudes T, Galizia CG, Martinelli E, Lavra L, Paolesse R, Ulivieri A, Catini A, Capuano R, Di Natale C (2014)
More than Apples and Oranges - Detecting Cancer with a Fruit Fly’s Antenna.
Scientific Reports 4 (January 6, 2014). doi:10.1038/srep03576.

Strauch M, Müthing C, Broeg MP, Szyszka P, Münch D, Laudes T, Deussen O, Galizia CG, Merhof D (2013)
The looks of an odour - Visualising neural odour response patterns in real time.
BMC Bioinformatics 2013, 14(Suppl 19):S6  

Münch D, Schmeichel B, Silbering AF, Galizia CG (2013).
Weaker ligands can dominate an odor blend due to syntopic interactions. Chem Senses. doi: 10.1093/chemse/bjs138

Münch D, Galizia CG (2011)
DoOR: The Database of Odorant Responses. Chemo Sense 13: 2-6

Galizia CG, Münch D, Strauch M, Nissler A, Ma S (2010)
Integrating heterogeneous odor response data into a common response model: A DoOR to the complete olfactome.
Chemical Senses 35: 551-563

Daniel Münch, Benjamin Schmeichel, Ana F. Silbering and C. Giovanni Galizia (2013) Early mixture processing in Drosophila olfaction ESITO XIII - European Symposium for Insect Taste and Olfaction, September 22nd - 28th 2013, Villasimius, Italy

Daniel Münch, Thomas Laudes, Jennifer S. Ignatious Raja, Anja Nissler and C. Giovanni Galizia (2015) Odor responses of Drosophila receptor neurons – Response profiles, mixtures and individual response dynamics.  11th Meeting of the German Neuroscience Society, March 18.–21.2015, Göttingen

Daniel Münch, Thomas Laudes, Jennifer S. Ignatious Raja, Anja Nissler and C. Giovanni Galizia (2015) Olfactory signaling on the Drosophila antenna – response profiles, mixtures and individual response dynamics.  Annual meeting of the Society for Neuroscience 2014, 15. – 19. Nov 2014, Washington DC

Daniel Münch, Thomas Laudes, Jennifer S. Ignatious Raja, Anja Nissler and C. Giovanni Galizia (2015) Olfactory signaling on the Drosophila antenna – response profiles, mixtures and individual response dynamics. 9th FENS Forum of Neuroscience, 05. – 09. July 2014, Milan

Daniel Münch, Benjamin Schmeichel, Ana F. Silbering and C. Giovanni Galizia (2013) Dominance of weaker ligands in a complex odor mixture. Fourth Annual Meeting of the SPP Active Groups, June 13-14 2013, Jena

Daniel Münch, Benjamin Schmeichel, Ana F. Silbering and C. Giovanni Galizia (2013) Dominance of weaker ligands in a complex odor mixture. 10th Göttingen meeting of the German Neuroscience Society, March 13-16 ,2013, Göttingen

Daniel Münch, Ana F. Silbering, Benjamin Schmeichel, C. Giovanni Galizia (2012) Mixture interactions in the periphery of the olfactory system - What does banana smell like? 105th Annual Meeting of the German Zoological Society, September 21-24, 2012, Konstanz

Thomas Laudes, Daniel Münch, Jennifer S. Ignatious Raja,  C. Giovanni Galizia (2012) New data for the Database of Odorant responses - DoOR. 105th Annual Meeting of the German Zoological Society, September 21-24, 2012, Konstanz

Münch D, Ignatious Raja JS, Thoma M, Galizia CG (2011) Response profiles of three olfactory receptors - The open DoOR towards the Drosophila olfactome widens. Annual meeting of the Society for Neuroscience 2011, Washington 12. - 16. Nov 2011

Ignatious Raja JS, Münch D, Thoma M, Galizia CG (2011) Response profiles of the Drosophila olfactory receptors Or42b and Or69a - knocking on the DoOR. Ninth Göttingen meeting of the German Neuroscience Society, 23. – 27. März 2011

Münch D, Schmeichel B, Pfeiffer S, Silbering A, Galizia CG (2009) Mixture interactions on the antenna of Drosophila melanogaster. March 25.–29.2009, 8^th Göttingen Meeting of the German Neuroscience Society

Ma S, Strauch M, Münch D, Galizia CG (2009) A DoOR to the complete olfactome: a common response model for the integtration of heterogeneous odor-response data. ESITO, Villasimius, Italy, September 2009.